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It is possible. But the extent of cybernetics isn't truly revealed. But I think Shepard will live longer.RS Kossery 10:17, November 4, 2011 (UTC)

He isn't a robot. Cybernetics are the glue who keeps Shepard bones and tissues together, nothing more. Shep fan 02:09, November 5, 2011 (UTC)

It's possible. Shepard does seem to be more hardier than stock humans. However... I believe Miranda will outlive him/her due to being designed to be long lived (relative to typical human lifespans) and despite being older than Shepard