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Working on the assumption you are refering to the heavy weapon found in Mass Effect 2, the Cain and Blackstorm weapons have a 'charge-up time', my guess is you should try "Press & Hold" the Attack key (LMB Default on PC) for 4 seconds to fire a round with Cain 3 seconds with Blackstorm

  • The Cain must be charged at 100% or higher or else it will not fire.

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